Several HLA haplotypic factors for both Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes
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Dental damages in non-insulin dependent diabetes patients
Introduction: Changes in saliva and its biochemical content in diabetic patients can effect on supportive dental tissues and cause dental damage. Low carbohydrate diets, and good control of disease can reduce dental damage in diabetics. The aim of this study was to compare dental damage in patients with non-insulin dependent diabetes mellitus (NIDDM) patients and healthy individuals. Methods: ...
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findings related to the epidemiology and natural history of the disease. Risk factors influence the risk of disease occurrence but, in most cases, are not the causal factors. For instance, prosperity and abundance of food do not directly cause obesity but may increase its incidence by making the causal exposure (food intake) more likely. A narrower definition of risk factor assumes that modific...
متن کاملAge-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.
The association of insulin-dependent diabetes mellitus (IDDM) with certain HLA alleles is well documented in pediatric patients. Whether a similar association is found in adult-on-set IDDM is not clear, although the disease occurs after the age of 20 in 50% of cases. HLA class II DRB1, DQA1, and DQB1 alleles were studied in 402 type I diabetics and 405 healthy controls (all Caucasian) using oli...
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A number of fascinating reports discussed treatment with metformin. Jones and colleagues studied 82 children with type 2 diabetes aged 10 to 16 years who had an average HbA1c of 8.6%, fasting glucose of 182 mg/dL, and weighing 92 kg. Results of this study showed that metformin at a dose of 500-1000 mg twice daily lowered fasting glucose levels by 43 mg/dL in 40 patients. Patients in the control...
متن کاملHLA-DR antigens in insulin-dependent diabetes.
HLA-A, B, C, and DR-typing was performed in 51 children with insulin-dependent diabetes. A close association between childhood diabetes and HLA-DR3 and DR4 was established. DR3 was found in 55% and DR4 in 75% of the diabetic children, compared with 20% and 26% respectively in healthy controls. The combination of DR3 and DR4 was present in 37% of the diabetic children compared with only 4% of th...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1983
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00251901